Poly(amino acid) based fibrous membranes with tuneable in vivo biodegradation

In this work two types of biodegradable polysuccinimide-based, electrospun fibrous membranes are presented. One contains disulfide bonds exhibiting a shorter (3 days) in vivo biodegradation time, while the other one has alkyl crosslinks and longer time (more than 7 days). According to mechanical measurements, tensile strength is comparable those soft connective tissues visceral tissues. Furthermore, suture retention test suggests, that would withstand surgical handling fixation. The biocompatibility study demonstrates how undergo hydrolysis by 3 rd day they become poly(aspartic acid) membranes, which can be then enzymatically degraded. After week, crosslinked almost completely degrade, alkyl-chain ones mildly lose their integrity as surrounding tissue invades them. Histopathology revealed mild acute inflammation, diminished minimal level after seven days.